Multimodal Treatment in Glioblastomas
نویسندگان
چکیده
منابع مشابه
Performance of adjuvant treatment correlates with survival in reoperated glioblastomas.
Objective To analyze cases of recurrent glioblastoma subjected to reoperation at a Brazilian public healthcare service. Methods A total of 39 patients subjected to reoperation for recurrent glioblastoma at the Department of Neurosurgery, São Paulo Hospital, Federal University of São Paulo, from January 2000 to December 2013 were retrospectively analyzed. Results The median overall survival ...
متن کاملMultimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas
PURPOSE To use perfusion and magnetic resonance (MR) spectroscopy to compare the diffusion tensor imaging (DTI)-defined invasive and noninvasive regions. Invasion of normal brain is a cardinal feature of glioblastomas (GBM) and a major cause of treatment failure. DTI can identify invasive regions. MATERIALS AND METHODS In all, 50 GBM patients were imaged preoperatively at 3T with anatomic seq...
متن کاملNFKBIA deletion in glioblastomas.
BACKGROUND Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding nuclear factor of κ-light polypeptide gene enhancer in B-cells inhibitor-α), an inhibitor of the EGFR-signaling pathway, promotes tumorigenesis in glioblastomas that do not have alterations of EGFR. ...
متن کاملHistopathological investigation of glioblastomas resected under bevacizumab treatment
To date, no clinical observations have been reported for histopathological changes in human gliomas under antiangiogenic treatment.We collected six glioblastomas resected under bevacizumab treatment. Histopathological investigation was performed by hematoxilyn-eosin staining and immunohistochemistry for CD34, VEGF, VEGFR1/2, HIF-1α, CA9, and nestin as compared to eleven control glioblastomas to...
متن کاملIntracranial Glioblastomas: New Hope for an Effective Treatment
According to the National Brain Tumor Society, over 120 different types of human brain tumors have been described, the most common of which are gliomas arising from glial (supportive) cells. Approximately two-thirds of brain tumors are benign, but about one third aremalignant. Themost common adult-onset primary (i.e., arising from the brain itself) malignant brain tumor is glioblastoma multifor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Sinir Sistemi Cerrahisi Dergisi
سال: 2021
ISSN: 1306-4126
DOI: 10.5222/sscd.2021.83703